THE JASON DI TULLIO FOUNDATION
Research Strategies in Glioblastoma
Goal: Implement a new treatment strategy in Glioblastoma
to improve patient outcome
Cancer cells in glioblastoma tumors proliferate rapidly, use newly developed cancer blood vessels to support their growth, spread to surrounding normal brain tissue, adapt and resist to treatment through multiple survival pathways.
Credit: iStock
Credit: Dr. S. Sabri & Dr. B. Abdulkarim Research Laboratories
Objectives and Research Strategies in Glioblastoma:
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Advances in molecular diagnostic, image-guided surgery, dose fractionation and delivery of radiation therapy, proton therapy.
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Understand the functions of altered genes and identify cellular targets required for survival of glioblastoma tumor cells.
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Design and test treatments to inhibit the ability of glioblastoma cells to grow, divide, spread, interact with the tumor microenvironment, and selectively kill glioblastoma cells.
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Use glioblastoma tumor cells resistant to chemotherapy and radiotherapy to analyze and overcome their mechanisms of resistance to treatment.