Clinical Research
Retrospective Clinical Studies:
-
Identify specific genes or proteins as biomarkers in glioblastoma tumors or biological fluids (blood or urine) to inform about patient outcome (prognosis) and predict response to treatment. Further validation in a clinical trial is required.
Clinical Trials:
-
Evaluate the safety and efficacy of treatment in patients, while integrating scientific, clinical, statistical and ethical approaches in a highly regulated clinical setting.
-
Eligible Patients sign an informed consent form to participate to the clinical trial.
-
The medical team monitors and evaluates side effects, tumor progression, patient survival and new biomarkers to predict response to treatment.
Credit: Dr. S. Sabri & Dr. B. Abdulkarim Research Laboratories
Treatment Strategies Tested alone or in Combination in Clinical Trials:
-
Chemotherapy and different modalities of radiotherapy
-
Targeted therapies to inhibit specific cellular targets or interactions with the tumor microenvironment
-
Immunotherapy to direct the immune system towards attacking glioblastoma cancer cells.
-
Repurposing drugs clinically approved for another disease for a new use in glioblastoma based on the ability to inhibit a survival pathway in the tumor.
-
Natural products to prove efficacy and safety before approval.